5 Radiobiology of LDR, HDR, PDR and VLDR Brachytherapy

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1. Summary	3
2. Introduction	4
3. Radiation Effects and Tissue Responses	4
4. Dose - Time Patterns in BT	5
5. The four R’s of Radiobiology and the Dose Rate Effect	6
6. Mathematical modelling of different dose rates and the EQD2 concept	8
7. Biological effects of dose inhomogeneity	12
8. Volume, anatomical site, and patient-related effects	12
9. Clinical Results: LDR, MDR, HDR and PDR BT	13
10. Practical Applications	16
11. Key messages	17
12. References	18

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