2016_Head & Neck COURSE BOOK

SCC Gene Expression

Mutated genes in H&N

Gene symbol

Function

Targets

TX

Mut rate

Tumor

p21,BAX, PUMA

Adenovirus based l t repa cemen

TP53

40-60%

suppressor

NOTCH1

Bivalent

Hes/Hey, p21 Secretase i

15%

Dsi: MEK/AKT i Farnesyltransferase Antisense

Raf/MEK/ERK PI3K/AKT

HRAS

Oncogene

4-35%

PI3Ki Dsi: Akt, mTOR

Akt, PLCgamma1

6-8%

PIK3CA

Oncogene

Tumor suppressor

CDKN2A

CDK 4/6

CDKi

9%

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