2016_Head & Neck COURSE BOOK

Xerostomia

Amifostine recommended by ASCO for RT but not for CRT. d d h d 2 f % 3 % ( - re uce c ronic xerostomia gra e rom 57 to 4

P = .

002)

.

Pilocarpine approved by FDA. - N =249 - patients randomized between placebo versus pilocarpine 5 mgr

N=249

P-value P 0 05 < .

P reservat on o sa vary unct on i f li f i

Quality of life

P=NS

Gustatory stimuli (chewing, acid substance, saliva substitute, ..)

Buglione et al, Critical Reviews Oncology/hematology 2016 Hensley et al. JCO 2009 Fisher J Int J Radiat Oncol Biol Phys 2003