2016_Head & Neck COURSE BOOK

Xerostomia

d l ( ) Intensity mo u ate ra iation t erapy IMRT d d h

- PASSPORT phase III trial compared IMRT with to conventional RT - n=94

IMRT

Conventional

Grade 2 xerostomia at 12 months ra e xerostom a at mont s G d 2 i 24 h

37% 29%

74% 83%

p< 0.05

- No difference in terms of PFS, OS, and other late toxicities Nutting et al. Lancet Oncol 2011