2016_Head & Neck COURSE BOOK

Skin toxicity: Radiation dermatitis

Radiation

RT RT+CT Systemic treatment

dermatitis 3/4

RTOG 95 01 -

21% 14% Cisplatin 100 mg/m2 day 1 22 43 , , ,

RTOG 91-11

9% 7% Cisplatin 100 mg/m2, day 1, 22,43

Bonner

18% 23% Cetuximab

Around 15-20% related to:

the total dose of RT and the RT field, the dose per fraction, CT or cetuximab

Cooper et al. NEJM 2004 Forastiere et al. NEJM 2003 Bonner et al. NEJM 2006