2016_Head & Neck COURSE BOOK

Systemic skin toxicity with anti-EGFR

B

C

D

(A) Papular lesions on the chest; (B) papulopustular eruption on the back; (C) l f f lli l t l (D) fl t t l th 60-80% Macular, papular, p stul r rash, = acne-like rash (or folliculitis) c ose-up o o cu ar pus u es; con uen pus u es on e nose Sometimes: severe pruritus Segaert S, Van Cutsem E. Ann Oncol 2005