2016_Head & Neck COURSE BOOK

Systemic skin toxicity with anti-EGFR

Mild

Antiacne or antirosacea (erythromycin or clindamycin gel)

Topical corticosteroids

Antihistaminic if itching

Oral tetracycline: i.e. minocycline 100 mg/day (pustule)

Severe Paronychia: hygiene, Potassium permanganate soak, topic steroids and antibiotics, silver nitrate Segaert S, Van Cutsem E. Ann Oncol 2005