2016_Head & Neck COURSE BOOK

Issues related with chemotherapy

Cisplatin

Nephrotoxicity Peripheral neuropathy Ototoxicity Less hematotoxicity than carboplatin Conditions for cisplatin administration Creatinine Clearance > 60 ml/min N t hil t 1000/ 3 eu rop coun > mm Platelet count > 75 000/mm3

Although not cardiotoxic be sure that the patients has a heart function , compatible with administration of 4 liter of saline solution in less than 24 hours