2016_Head & Neck COURSE BOOK

Issues related with chemotherapy

Grade 3/4

Vermorken

Posner

PF vs TPF 52.5% 76.9% 17 9% 5 2% . . 2.8% 5.2% 6.1% 6.9% 11.2% 4.6%

PF

vs TPF

Neutropenia Th b i rom open a

56% 83%

11%

4%

Febrile neutropenia

7% 12%

Infection Stomatitis

5%

6%

27% 21%

Prophylactic antibiotics, ciprofloxacine 500mg bid started day 5 for 10 days Consider prophylactic G-CSF

Posner et al. NEJM 2007; Vermorken et al. NEJM 2007