2016_Head & Neck COURSE BOOK

Randomized trials mono vs polychemotherapy

Median survival (months)

Regimens

N ORR (%)

5.5 5 6.1

249

32% 17% 13%

Cisplatin/5-FU vs Cisplatin vs 5-FU

382

34%

8.2

Cisplatin/methotrexate/ bleomycine/vincristine vs Cisplatin/5-FU vs Cisplatin

31% 15%

6.2 5.3

Jacobs et al JCO 2002, Clavel et al Ann Oncol 1994, Forastiere et al JCO 1992