2016_Head & Neck COURSE BOOK

Platin/5-FU vs platin/5-FU plus cetuximab

EXTREME Trial: first line palliative treatment

Platinum-5FU

R

Platinum-5FU + cetuximab Cetuximab monotherapy 6 chemotherapy cycles until PD or toxicity

N= 442

Primary endpoint: survival

Vermorken et al, NEJM, 2008