2016_Head & Neck COURSE BOOK

Validating the hypoxia classifier Independent clinical dataset

414 patients enrolled in the DAHANCA 5 trial

219 randomly assigned to radiotherapy and nimorazole

195 randomly assigned to radiotherapy and placebo

52 excluded from classification (2 failed in PCR, 50 did not

39 excluded from classification (1 failed in PCR, 38 did not

have tumour tissue for PCR)

have tumour tissue for PCR)

Nimorazole group: 167 for classification 323 t

Placebo group: ifi ti 156 for classification l

l f umour samp es or c ass ca on

Classification (209) s” hypoxic (209)

”More” hypoxic

”Less” hypoxic

(114)

Toustrup K et al, Radiother Oncol; 102; 122-129, 2012