2016_Head & Neck COURSE BOOK

RT + EGFR inhibition synergies

Ionizing radiation 

/ G2 M‐block

EGFr‐I

G1‐ block

• EGFr‐I induces apoptosis  (~ 2 fold) • RT induces apoptosis (6 Gy – 2 fold)

• RT and EGFr‐I synergistic effect  (5‐6 fold)

Huang SM Cancer Res 1999;  Harari PM IJROBP 2001;  Nyati MK Clin Cancer Res 2004