2016_Head & Neck COURSE BOOK

Hypoxia-classification 15-gene hypoxia classifier

• Based on hypoxia induced genes (in vitro/in vivo validated) • Classification based on gene expression similarity to either ”more” or ”less” hypoxic tumours as estimated with pO 2 -electrode in an independent trainingset of 58 H&N cancer patients

100

pO 2 -measurements < 2,5 mmHg

80

60

40

Hypoxic fraction (%) 0 20

0

5

10

15

20

25

30

35

40

45

50

55

Head and neck tumours (n=58)

Toustrup K et al, Cancer Res; 71(17); 5923-31, 2011

Less Hypoxic

More Hypoxic