2016_Head & Neck COURSE BOOK

Overall Survival and DFS

Overall survival

Disease-free survival Hazard Ratio: 0.83 (95% CI: 0.62-1.12)

80 90 100

100

50 60 70 80 90 10 20 30 40

HR: 0.88 (95% CI: 0.65 - 1.19) P=0.0015 for non-inferiority of LP

50 60 70 10 20 30 40

Larynx preservation

Larynx preservation

Median, 44 mo

Surgery Median, 25 mo

Surgery

0 2 4 6 8 10 12 14 16 0 O N Number of patients at risk : 81 94 49 36 26 14 9 5 3 83100 62 47 27 17 8 4 1

(years)

0 2 4 6 8 10 12 14 16 0 O N Number of patients at risk : 88 94 37 25 16 6 5 1 0 88100 47 32 19 10 5 2 1

(years)

Surgery LP

Surgery

Preservation

Lefebvre JL, et al. ASCO 2004: Abstract 5531.