2016_Head & Neck COURSE BOOK

CRT: Late toxicity • Analysis of 230 patients receiving CRT in 3 studies (RTOG 91-11, 97-03, 99-14) • Factors associated with development of severe late toxicity a – Older age (p=0.001), advanced T-stage (p=0.0036), larynx/hypopharynx primary (p=0.004), neck dissection after RT (p=0.018) 50 43% 40

27%

s (%) 20 30 Patient

13%

12%

10%

10

0

Any severe late toxicity

Feeding tube dependence >2 yrs post-RT

Pharyngeal dysfunction

Laryngeal dysfunction

Death

a Chronic grade 3 4 pharyngeal/laryngeal toxicity and/or requirement for feeding tube >2 years after registration and/or - potential treatment-related death within 3 years

Machtay M, et al. J Clin Oncol 2008;26: e-pub June 16