2016_Head & Neck COURSE BOOK

Study Design N = 220 patients (7 ineligible)

110 in TPF arm and 103 in the PF arm

Total Laryngectomy + post-op RT for nonresponders

PF x 3

Response to induction treatment

R

RT alone for responders

TPF x 3

Primary endpoint:

• Larynx preservation

Secondary endpoints

• Overall survival, DFS, toxicity

Calais G, et al.