

RISK FACTORS
•Bile – gastric reflux
•Genetic susceptibility
Alcohol metabolism
( l
hi
f ld h d d h d
)
po ymorp sms o a e y e e y rogenase
CYP2E1
DNA repair / Cell cycle control
•Genetic syndrome
(Fanconi’s aniemia / Dyskeratosi congenita)
•Batel quid and gutka
HPV
(see below)
21