2016_Head & Neck COURSE BOOK

Summary key points  – 

M difi d f o e ract onat on yper ract onat on an or acceleration) is superior to conventional fractionation • Hypoxic sensitizers (e g nimorazole) improves tumor control . .  and survival without enhancing radiation morbidity • Concomitant platinum‐based chemotherapy is more effective  than RT alone for younger patients in good performance  status with and advanced stage tumours. Acute and late toxicity is increased • EGFR inhibition combined with radiotherapy (but not  chemoRT) results in enhancement of tumor response • The optimal combination of these ’radiotherapy intensifiers’ is  still unsettled i i (h f i i d/ •