2016_Head & Neck COURSE BOOK

Prognosis

Prognostic factors in patients with recurrent or metastatic SCCHN treated with cisplatin- based chemotherapy in two phase III trials (E1393 and E1395)

• 0-2 unfavorable prognostic factors: median OS = one year. • 3-5 unfavorable prognostic factors: median OS = six months (p < 0.0001) Prognostic factors for poor survival in the multivariate analysis (n=399) p Weight loss > 5% 0.0004 ECOG 1 vs 0 0.0016 Well and moderate differentiation 0.028 Primary tumor oral cavity or hypopharynx 0.011 Prior radiation therapy <0.0001

Argiris et al Cancer 2004