2016_Head & Neck COURSE BOOK

immune response

Priming phase

Effector phase

Tumor cell

T cell

T cell

Dendritic cell

Peripheral tissue

Lymph node

MHC

TCR

TCR

MHC

B7 CD28 Activation signals

Negative signals

PD-1

PD-L1

Inhibitory signals

B7

CTLA- 4

CD28

Antibody Antibody

Antibody

TCR = T-cell receptor; PD-L1 = programmed death-ligand 1.