2016_Head & Neck COURSE BOOK

Study Design

PF x 1→RT

CR, PR

N = 173

I d ti n uc on PF x 2

Response

Surgery→RT

SD, PD

R N = 172

Concurrent P x 3 + RT

N = 173

RT l

a one

P i r mary en po nt: Larynx preservat on Secondary endpoints: OS, DFS, laryngectomy-free survival Primary organ preservation with surgical salvage accepted for all 3 study arms. Neck dissection included N 2 N 3 disease. d i i Forastiere AA, et al. N Engl J Med 2003;349:2091-8; Forastiere AA et al. ASCO 2006. Abstract 5517.