2016_Head & Neck COURSE BOOK

IDENTIFICATION OF THE PRIMARY TUMOR

BIOLOGICAL STUDIES

DETECTION OF EPSTEIN-BARR VIRUS IN A LYMPH NODE BIOPSY IS USEFUL TO DETECT NASOPHARYNGEAL CARCINOMA IN THE AREAS WHERE THE DISEASE IS ENDEMIC, OTHERWISE, ITS VALUE IS LIKELY LIMITED

EBV

92% TYPE 16 (FOLLOWED BY TYPE 18, 33 AND 58)

STRONGLY ASSOCIATED WITH THE PRESENCE OF CYSTIC CERVICAL METASTASIS

HPV

DETERMINATION OF HPV STATUS CAN BE OBTAINED BY FNAC

95% OF SCC HPV+ ARE NON KERATINIZING 85% OF SCC KERATINIZING ARE HPV -

Lee et al.,Head Neck 2000 Gillison et al., J Natl Cancer Inst 2008 Desai et al., Exp Mol Pathol 2009 Vent el al., Head Neck, 2013 Pavlidis et al., Oral Oncology 2015 von Buchwald C et al, 2014 Pawlita et al, Clin Exp Metastasis, Sept 2015 Lewis et al, Head and Neck Patol, 2015

HPV RELATED SCC ARE GENERALLY DIAGNOSED WITH EARLIER T CATEGORY AND MORE ADVANCED N CATEGORY

mercoledì 29 giugno 16