2016_Head & Neck COURSE BOOK

HPV AND NECK METASTASIS FROM UNKNOWN PRIMARY

Can HPV positivity or overexpression of p16 be used as surrogate markers guiding the localization of the primary tumor??? …HPV is a probable causative agent

1. etiological association 2. ICH staining for HPV in every biopsy

Fotopoulos et al, Oral Oncology (2015)

UP is a distinct pathologic entity, similar to oropharyngeal and nasopharyngeal virus-related malignancy carcinoma , particularly when in the presence of a bulky IIA node in which high-risk HPV/EBV detection is 70%

Bussu et al, Ann Surg Oncol (2015)

p16-positive status

Associated with younger age , nonsmoker status , and lower disease burden at presentation

Low-risk UP patients for potential treatment de-escalation

Dixon et al, Head Neck (2016)

mercoledì 29 giugno 16