2016 Hematological Malignancies

Correlation of dose and efficacy Cytostatic drugs in vitro

1.0

0.1

Methotrexate Vincristine Ara-C

0.01

Cyclophosphamide Carboplatinum

0.001

BCNU

Surviving Fraction MCF7 (breast cancer) 0.0001

Thiotepa

Melphalan

0.00001

4 10 Dose (multiples of IC 90 ) 6 8

2