2016 Hematological Malignancies

Change of RCHOP in DLBCL

Study

Pt no iPET timing Intervention

End point

Pradal (GELTAMO) 2015 Swinnen (ECOG) 2014

71

>3 cycles MegaCHOP

-ve: 3 MegaRCHOP +ve: 2 RICE + BEAM ASCT (no info on RT)

3y PFS: -ve: 81%, +ve: 57% OS: -ve: 95%, +ve 33%

74

> 3 RCHOP -ve: 3 RCHOP +ve: 4 RICE (no RT)

2y PFS -ve: 76%, +ve: 42% OS -ve: 93%, +ve 69%

Duehrsen (PETAL) 2014

853 (926)

> 2 RCHOP -ve: randomise to 4 RCHOP or 4 RCHOP + 2R +ve: randomise to 4 RCHOP or intensification

2 R: no difference (HR 1.2, 95%CI 0.8-2.1) Intensification: no difference (HR 1.6, 95%CI 0.9-2.7) 4y PFS -ve: 91%, +ve: 59% OS -ve: 96%, +ve 73%

Sehn (BCCA) 2014

155

> 4 RCHOP -ve: 2 RCHOP

+ve: 4 RICE + RT for EOT PET +ve -ve: continue RCHOP +ve: 2 ESHAP or ICE + ASCT RT permissible

Kasamon 2009

59

> 2-3 RCHOP

2y EFS -ve: 89%, +ve: 67%