2017_IGRT course book

Estimate pattern of spread from response to incidental dose in clinical trial data (high risk prostate patients)

Average dose no failures – average dose failures

≈ 7 Gy p = 0.02

-

=

PSA controls

PSA failures

1.0 100%

≥ median

0.8 80%

0.6 60%

0.4 40%

< median (53.1 Gy)

0.2 20%

Free from any failure

Treatment group IV, Hospital A (n=67) p = 0.000

0.0

0%

0

12

24

36

48

60

72

0

6 Y

3

Time (months)

Witte et al, IJROBP2009; Chen et al, ICCR2010