2017_SBRT_Course Book

Published data about SBRT for Prostate cancer

Biochemical control

Late toxicity

Phase I/II

No .of. Patients

Risk Category

Median Follow Up

Series

Median Follow-Up

Robotic SABR King

King 2013 Katz 2014

1100 All risk groups

36 months

2.7 years 72 months 28 months 24 months Low-dose 27 months High-dose 37 months 30 months

Katz Chen

477

Low/Intermediate

72 months

Friedland

Oliai

Chen 2013

100

All risk groups

2.3 years

Freidland 2009

112

Low/Intermediate

24 months

Oliai 2012

70

All risk groups

27 months for low dose 37 months for high dose

Meier

Gantry-Based SABR Kim

Meier 2015

309

Low/Intermediate

3 years

24.5 months as per dose group

Loblaw 2013

84

Low

55 months

Menkarios 2012

80

Low risk

33 months

Mantz 2014

102

Low

Minimum 5 years

Menkarios

33 months 55 months

Loblaw Mantz

Kim 2014

91

Low/Intermediate

42 months

Minimum 5 years

Ø Few, early studies with small patient numbers and intermediate follow-up

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Toxicity

10 15 20 25 30 35 40 45 50

McBride et a. 2012 Madsen et al. 2007 Boike et al. 2011 King et al. 2012 Katz et al. 2011 Jabbari et al. 2012

0 5

Proportion of patients (%)

Acute GI

Late GI

Acute GU Late GU

Ø Late toxicity = preliminary Ø Relevant GU toxicity

Matthias Guckenberger - ESTRO SBRT Course 2017

07.09.17

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