2017_SBRT_Course Book

ADT and cardiac disease

• Prospective cohort study 7637 subjects, nearly 30% exposed to ADT • Multivariable analyses: In men without preexisting CVD, ADT was associated with an increased risk of heart failure (adjusted HR=1.81 , 95% CI 1.40–2.32 ) • Only among patients with preexisting CVD was elevated risks of arrhythmia (adjusted HR=1.44 , 95% CI 1.02–2.01), and conduction disorder (adjusted HR=3.11 , 95% CI 1.22, 7.91) observed

Haque R, BJC 2017