2017_SBRT_Course Book

Acquisition of resistance

Targeted Tx

„Oligo“ Resistance

„Systemic“ Resistance

Ø Development of acquired resistance unlikely a systemically parallel process but a cascade of sequential events

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Acquisition of resistance: A potential role for targeted radiotherapy

„Oligo“ Resistance

Restore Sensitivity

Targeted Tx

Ø Local eradication of the oligo-resistant tumor site(s) to restore a sensitive state and continue the systemic Tx

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