2017_SBRT_Course Book

Abscopal effect

„ab-scopus“ : away from the target

• Systemic tumor response induced by local radiotherapy

07.09.17 ESTRO SBRT COURSE 2017 - Matthias Guckenberger

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Cancer cell: immunogenic cell death

• Changes in the composition of the cell surface • Release of soluble mediators Ø Increased presentation of tumor antigens to T-cells via dentitic cells

Ø „ICD constitutes a prominent pathway for the activation of the immune system against cancer, which in turn determines the long-term success of anticancer therapies“ Kroemer Annual Review of Immunology 2013

07.09.17 ESTRO SBRT COURSE 2017 - Matthias Guckenberger

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