2017_SBRT_Course Book

Timing of RT and immunotherapy

A – Start of RT B – End of RT C – after RT

concurrent

sequential

Dovedi Cancer Res 2014

Ø Sequencing of RT and immunotherapy relevant Ø Concurrent application

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Combination of RT with immunotherapy

Melanoma mouse model

PDL1 C4 & PDL1

C4 & PD1

RT & C4 & PD1 / PDL1 80% Twyman-Saint Victor Nature 2015

0% 0% 20%

CR

Ø Relevant complete response rates only after radiotherapy and double checkpoint inhibition

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