2017_SBRT_Course Book

Systematic review: SRT & targeted drugs

Patients

Cranial

Extracranial

Antibodies anti-EGFR / VEGF / HER2 Bevacizumab

215

201

14

Trastuzumab Cetuximab anti-CTLA-4 Ipilimumab anti-PD-1 Nivolumab

7

7 0

0

244

244

121

119

46

27

27

0

Small molecules EGFRi Sorafenib

61 76 71

45 75 43

61 62 48 39 20

Sunitinib

Gefitinib/Erlotinib

ALKi Crizotinib

39

15

BRAFi

129

128

MEKi Trametinib Total

4

4

0

994

664

534

Kroeze Cancer Treat Rev. 2017

• 0 - 20

21 – 100

>101

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Systematic review: SRT & targeted drugs

Kroeze Cancer Treat Rev. 2017

• Overall, few grade IV and grade V toxicities • Less toxicity in brain SRS compared to SBRT

07.09.17 ESTRO SBRT COURSE 2017 - Matthias Guckenberger

42

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