2017_SBRT_Course Book

„High-dose“ re-irradiation

Study

Patients (#)

Interval (months)

Re-irradiation (Gy)

Cumulative (Gy)

51 50 56 50 40 60

Wu 2003

23

13

NS

110

Okamoto 2002

34

23

Kruser 2013

48

19

NS

Tada 2005

14

16

NS

Ebara 2007

44

13

102

120

Griffioena 2014

24

51

Ø Selected patients: long interval and median target size <100cc in all studies basis for full dose Re-RT Drodge Ann Palliat Med 2014

07.09.17 ESTRO SBRT 2017 - Matthias Guckenberger

33

/

„High-dose“ re-irradiation

Study

Toxicity G V

Median OS

Wu 2003

0 0 0 0 0

14 15 13

Okamoto 2002

Kruser 2013 Tada 2005 Ebara 2007

7 7

Griffioena 2014

N=3

14

Ø Relevant but manageable toxicity Ø Reasonable OS Drodge Ann Palliat Med 2014

07.09.17 ESTRO SBRT 2017 - Matthias Guckenberger

34

/