2017_SBRT_Course Book

Endothelial response to high RT doses

MCA 129 fibrosarcoma and B16F1 melanoma grown in apoptosis resistant acid sphingomyelinase (asmase)-deficient or Bax-deficient mice

Reduced tumor endothelial apoptosis in asmase -/- mice. Tumors grew 2-4 x faster than in the wild-type.

Tumors with apoptosis-resistent vascular endothelium Were resistant to radiation

Endothelial apoptosis was observed with doses >8 Gy in wild-type endothelium.

Science 300: 1155; 2003