2017_SBRT_Course Book

Abscopal effects with GM-CSF Phase I data

30%

GM-CSF: A potent stimulator of dendritic cell maturation

Abscopal response In 11/41 pts (27%)

35 Gy/10 frx

35 Gy/10 frx

Responders: NSCLC: 4/18 (2 CR)

Breast: 5/14 Thymic: 2/2

Patients with stable or progressing metastatic solid tumours, on single-agent chemotherapy or hormonal therapy, with at least three distinct measurable sites of disease

Golden et al. Lancet Oncol 2015; 16: 795