2017_SBRT_Course Book

Dose effect relationship in NSCLC

40Gy 50Gy 60Gy

• High irradiation doses required for local tumor control • Effect on OS limited due to competing risk of systemic progression Perez Cancer 1987 Martel Lung Cancer 1999

Matthias Guckenberger - ESTRO SBRT Course 2017

07.09.17

5

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Dose effect relationship in SBRT for NSCLC

Onishi Cancer 2004

Ø Dose effect relationship in SBRT Ø Local tumor control and OS Ø LQ model for adjustment of variable dose per fraction All patients Medically operable patients

Matthias Guckenberger - ESTRO SBRT Course 2017

07.09.17

6

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