2017_SBRT_Course Book
What dose is now actually required? n=505 n=395
1.0
0.9
0.8
0.7
0.6
0.5
0.4
Local control
0.3
0.2
0.1
0.0
0
20
40
60
80 100 120 140 160 180 200
BED 10
Perscription dose PTV (Gy)
Grills JTO 2010; Ohiri IJROBP 2012
Guckenberger Radiother Oncol 2013
= 3 x 18Gy
Ø Very limited gain in TCP for doses >100Gy BED
Matthias Guckenberger - ESTRO SBRT Course 2017
07.09.17
17
/
Late recurrences in stage I NSCLC
Japanese prospective study: N=180
Swedish phase II trial: N=57
Shibamoto JTO 2015
Lindberg Acta Oncol 2015
Median FU 52.5 months 4 x 11-13 Gy @ isocenter
Median FU 41.5 months 3 x 15Gy @ 67%
• Very few recurrences after 3 – 5 years Ø Validity of TCP modelling
Matthias Guckenberger - ESTRO SBRT Course 2017
07.09.17
18
/
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