2017_SBRT_Course Book

Dose escalation WITHIN the PTV Central location Prostate Spine

Urethra Ø Scricture

Bone Ø Fracture

Bronchi Ø Stenosis

Ø Adaptation of dose profile within the PTV

Matthias Guckenberger - ESTRO SBRT Course 2017

07.09.17

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C O N C L U S I O N S Ø Dose explains high rates of local tumor control Ø LQ model describes reasonably well what we observe in clinical practice Ø Dose-response not different between primary NSCLC and pulmonary metastases Ø PTV encompassing dose >100Gy BED achieves >90% TCP Ø Total dose adapted to competing risk of death / distant progression Ø Fractionation adapted to risk of OAR toxicity

Matthias Guckenberger - ESTRO SBRT Course 2017

07.09.17

30

/