2017_SBRT_Course Book

Recent randomized studies in Radation Oncology

Study characteristic published in 2015

Median age at diagnosis (SEER)

Tumor entity Study question

Median age Maximum age

54 years 75 years

61 years

Breast

RT of mammaria interna

54 years 84 years

61 years

Breast

RT of mammaria interna

Dose escalation Cetuximab Adjuvant CT after neoadjuvent RCHT

64 years 83 years

70 years

NSCLC

62 years 68 years

68 years

Rectal

72 years 85 years

66 years

Prostate

Duration AHT

Hypofractionation of RT

71 years 75 years

66 years

Prostate

Ø Lack of evidence covering elderly patients

ESTRO SBRT COURSE 2017 - Matthias Guckenberger

07.09.17

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Treatment given to patients with curable stage I NSCLC

Overall population SEER > 65 years

Netherlands >75a

11%

13%

29%

Surgery RT BSC

Surgery RT BSC

Surgery RT BSC

Raz Chest 2007

Shirvani IJROBP 2012 Haasbeek Ann Oncol 2012

Ø 1/3 of all patients >75 old remain untreated

ESTRO SBRT COURSE 2017 - Matthias Guckenberger

07.09.17

10

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