207_Combined course Presentations
Impact of IMRT compared to 3D-CRT: Heart dose
Overall survival univariate analysis
Co-variate
HR
95% CI
P-value
Heart Doses
Heart V20 1.008 1.004, 1.013 0.0005
Heart V40
1.013
1.006, 1.021 0.0005
Heart Doses
3D-CRT IMRT P-value
Heart V60
1.023 1.007, 1.039 0.0051
V20
23.5% 19.3% 0.049
V40
11.4% 6.8% 0.003
Overall survival multivariate analysis
V60
2.4% 1.4% 0.045
Co-variate
HR 95% CI
P-value
Heart V40 1.013
1.005, 1.02 0.0008
CONCLUSION : in RTOG 0617 trial, IMRT was associated with lower rates of severe pneumonitis and cardiac doses , which supports routine use of IMRT for locally advanced NSCLC
Chun SG. et al. JCO 2017;35
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