207_Combined course Presentations
Neuroendocrine tumors of the lung
Carcinoid
Atypical Carcinoid
LCNEC SCLC
Mitoses/2mm 2 (10 HPF)
<2
2-10
>10
>10
Smoking
33% (general population)
64%
98%
97%
5 YR OS
92-100%
61-88%
13-57%
5%
Prevalence
1-2%
0.1-0.2% 1.6-3% 15%
TP53 mutation
6%
-
74%
90%
RB1 down-regulation
0%
21%
68%
87%
MEN mutation
18%
36%
0%
0%
Beasley et al. Human Pathol , 2003 Haruki et al. Jpn J can cer Res, 2000 Adapted from Swarts et al. BBA-Rev on Cancer ,2012
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