207_Combined course Presentations

National or institutional molecular screening programs in breast cancer and other advanced solid tumors predictive biomarker

Institution or National Program

Platform

Cancer(s)

Archival vs Biopsy

Timeframe

Additional Details

Massachusetts General Hospital

SNaP Shot

NSCLC, CRC, Melanoma, Breast

Archival

Ongoing

Includes somatic mutations in 14 oncogenes. In NSCLC, additional FISH panel for ALK rearrangements. Plan to integrate NGS technology in near future. $43 million investment over 5 years. Currently tests ~470 mutations in 41 genes. “T9 Program”. Customized Sequenom Panel (40+ genes) with Sanger confirmation.

Dana Farber Cancer Institute

OncoMap (Sequenom)

All solid tumors

Archival

Ongoing

MD Anderson Cancer Centre

Sequenom

All

Archival

Ongoing

Plan to screen “Ten Thousand Tumors”.