207_Combined course Presentations

Radiotherapy ± EGFR-I

Acute toxic effects (WHO criteria)

RT alone

RT + cetuximab

p - value

Mucositis (grade 3-5)

52%

56%

N.S.

Skin rash (all grades)

10%

87%

< 0.001

Radiation dermatitis (grade 3-5)

18%

23%

N.S.

Weight loss (all grades)

72%

84%

0.005

Nausea (all grades)

37%

49%

0.02

Fever (all grades)

13%

26%

0.001

Anemia (all grades)

13%

3%

< 0.001

Late toxicity: no difference

Bonner JA 2010

03/01/13