207_Combined course Presentations

HPV/p16 and HNSCC in the oropharynx

• Oropharynx cancer • Increasing incidence

DAHANCA 1977-2014

450

400

65%*

350

62%*

• Non-keratinizing SCC • p16 expression, p53wt

300

Larynx

250

200

70%*

• Younger age/more fit • Less smoking • Less alcohol • N+ (advanced disease) • Improved prognosis

55%*

150

Number of patients

Oropharynx

33%*

100

50

*HPV/p16+

42%* 37%*

0

1977 1982

1987 1992 1997 2002 2007 2012 2017

Year

Updated from Lassen 2010