207_Combined course Presentations

De-escalation: RTOG 1016: phase III

p16+ oropharyngeal carcinomas

T1-2,N2a-3 or T3-4 any N

RT 70Gy/35f/6 wks + cisplatin 100mg/m² x 2

Stratify: T 1-2 T3-4 N0-2a N2b-c Smoking Zubrod 1- 2

N=700 98 pts recruited before closure in July 2014

RANDOMIZE

RT 70Gy/35f/6 wks + cetuximab for 8 weeks

Reducing toxicity by replacement of cisplatin with cetuximab ?