207_Combined course Presentations

TRIAL

No

Median FU Primary endpoint Secondary endpoints

Overall survival

ACT 1 (UKCCR 1996)

585 42 months Local treatment failure (composite of local failure and colostomy)

Event-free survival

EORTC 22861 (Bartelink 1997) RTOG 87-04/ECOG (Flam 1996)

110 42 months Local failure

Disease‐free survival.

Overall survival Colostomy-free survival, Loco-regional control etc..

291 3 years

RTOG 98-11 (Ajani 2008)

644 2.51 years Disease‐free survival.

Overall Survival Cumulative incidence of Colostomy Overall survival Cancer-specific survival Local control etc.. Overall survival Cancer-specific survival Colostomy rate

ACCORD-03 (Conroy 2009)

307 43 months Colostomy-free survival

ACT II (CRUK) (James 2013)

940 61 months

Complete response Acute Toxicity Recurrence-free survival