207_Combined course Presentations

Disease Free Survival

Definition Time from randomisation to recurrence (in ITT population) Pros • Smaller population and shorter follow-up • Not affected by crossover or subsequent treatment (eg checkpoint inhibitors)

• ? Measure of direct benefit • Subject to assessment bias • Unreliable and imprecise timing • Need to balance radiological assessments ie need standardized follow-up protocols bias – if imbalanced withdrawal of patients who are censored prior to relapse or progression

Cons

Censor