207_Combined course Presentations

Role of RT in Advanced stage HL

 The role of consolidative RT on bulky lesions for advanced stage Hodgkin disease is controversial .

 Several studies have shown the beneficial role of consolidative RT in term of PFS (but not in term of OS). However these results were obtained with outdated RT (dose, fields and techniques) and CT (MOPP, Stanford V…) schedules.

 Nowadays consolidative RT on bulky lesions is related to the chemotherapy regimen and to the PET status at the end of it.

 Consolidative RT was not established, but left to the discretion of the treating physicians (bulky lesions or residual disease at the end of chemotherapy), by many recent randomized studies that tested the effect of ABVD regimen (e.g. RATHL study)