207_Combined course Presentations

IELSG 37 – Study Design

PMBCL diagnosis basal PET-CT 1

* RCHOP 14-21; R-V/MACOP-B DA-EPOCH-R; R-ACVBP; R-CHO(E)P like

Standard therapy R-Chemo

Positive not randomised pts will be followed for response, PFS and OS analysis of the chosen salvage strategy .

PET-CT 2 Central review

5-6 wks after R-Chemo

Positive

Negative

Random 1:1

8 wks after R-Chemo

Mediastinal RT 30 Gy

Observation

376 pts to randomize